منابع مشابه
Evaluating pharmacogenetic tests: a case example.
Work in human genetics is revealing genes that affect the safe and effective use of pharmaceuticals. Primary care physicians are already receiving advertisements for tests for these variations that emphasize the value of learning about their patients' susceptibility to adverse reactions in order to avoid them. We propose a strategy for the critical evaluation of such offers to ensure the optima...
متن کاملEconomic evaluation of pharmacogenetic tests.
Ever since the sequencing of the human genome was completed, prediction of treatment response in terms of genetic variation has been seen as an important and achievable goal. Pharmacogenetics is the study of how genetic differences affect variation in response to medication. One potential goal of pharmacogenetics is to be able to deliver "personalized medicine" by making management decisions th...
متن کاملPharmacogenetic tests for antipsychotic medications: clinical implications and considerations
Optimizing antipsychotic pharmacotherapy is often challenging due to significant variability in effectiveness and tolerability. Genetic factors influencing pharmacokinetics and pharmacodynamics may contribute to some of this variability. Research studies have characterized these pharmacogenetic relationships, and some genetic markers are now available as clinical tests. These advances in pharma...
متن کاملEvidence used in model-based economic evaluations for evaluating pharmacogenetic and pharmacogenomic tests: a systematic review protocol
INTRODUCTION Decision models can be used to conduct economic evaluations of new pharmacogenetic and pharmacogenomic tests to ensure they offer value for money to healthcare systems. These models require a great deal of evidence, yet research suggests the evidence used is diverse and of uncertain quality. By conducting a systematic review, we aim to investigate the test-related evidence used to ...
متن کاملEvaluating diagnostic tests
Anaesthesiologists are increasingly more involved in perioperative patient care wherein interpretation of special investigations is crucial to making therapeutic and prognostic decisions. Furthermore, anaesthetic journal publications increasingly rely on diagnostic tests, without paying sufficient attention to the methodology for evaluation of the predictive ability of these tests, particularly...
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ژورنال
عنوان ژورنال: Archives of Pediatrics & Adolescent Medicine
سال: 2004
ISSN: 1072-4710
DOI: 10.1001/archpedi.158.3.276